Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study

ÇİRİŞ İ. M. , BOZKURT K. K. , BAŞPINAR Ş. , Kapucuoglu F. N.

PATHOLOGY RESEARCH AND PRACTICE, cilt.207, ss.182-187, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 207 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.prp.2011.01.005
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Sayfa Sayıları: ss.182-187

Özet

Cyclooxygenase-2 (COX-2) is a prostaglandin synthase that catalyzes the synthesis of prostaglandin G2 and H2. It has been shown that COX-2 plays an important role in tumorigenesis of different tumor types and it is thought to take part in breast carcinogenesis. In the present study, we aimed to investigate the relationship of immunohistochemical COX-2 expression with clinicopathological parameters, including HER-2/neu overexpression in invasive breast carcinoma (IBC).