Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study
PATHOLOGY RESEARCH AND PRACTICE, cilt.207, sa.3, ss.182-187, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 207 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1016/j.prp.2011.01.005
- Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.182-187
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Cyclooxygenase-2 (COX-2) is a prostaglandin synthase that catalyzes the synthesis of prostaglandin G2 and H2. It has been shown that COX-2 plays an important role in tumorigenesis of different tumor types and it is thought to take part in breast carcinogenesis. In the present study, we aimed to investigate the relationship of immunohistochemical COX-2 expression with clinicopathological parameters, including HER-2/neu overexpression in invasive breast carcinoma (IBC).