Impact of clinical pharmacist’s interventions on clinical outcomes in appropriate use of colistin: a prospective pre-post intervention study

Albayrak A., Özger H. S., Başgut B., Aygencel Bıkmaz Ş. G., Karahalil B.

Journal of Chemotherapy, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1080/1120009x.2023.2196916
  • Journal Name: Journal of Chemotherapy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Colistin, clinical pharmacist, appropriate use, intensive care unit, nephrotoxicity, critical care, RISK-FACTORS, SOUTH-AFRICA, POLYMYXIN-B, NEPHROTOXICITY, COLISTIMETHATE, MORTALITY, ADULT, RATES
  • Süleyman Demirel University Affiliated: Yes


This study aims to evaluate the clinical pharmacist’s contribution impact on the appropriate use of colistin. Our study was conducted prospectively in patients in the Internal Diseases Intensive Care Unit of Gazi University Medical Faculty Hospital for eight months. The first four months of the study were with the observation group, while the next four months were with the intervention group. The study determined how the active participation of clinical pharmacists had affected the appropriateness of colistin use. The results showed that the appropriate use of colistin was higher in the intervention group than in the observational group; furthermore, incidence of nephrotoxicity was lower. The difference between both groups was statistically significant (p < 0.001, p < 0.05), respectively. This study showed that the clinical pharmacist’s active intervention by following the patients increased the frequency and percentage of the appropriate use of colistin. This decreased the incidence of nephrotoxicity, colistin’s most important side effect.