Research Information System
1. ULUSLARARASI SAĞLIK BİLİMLERİ VE YAŞAM KONGRESİ, Burdur, Turkey, 2 - 05 May 2018, pp.422
Colorectal carcinoma is ranked 4th after breast, prostate
and lung cansers. Etiology of carcinomas includes
heredity, nutrition, radiation, adenomatous polypes,
inflammatory intestinal disease.
Linum Usitatissimum is annual cultivated plant. It
contains lots of good quality protein and α-linolenic acid
and also it is natural source of flavonoids, which are
knows, lignin and fenolic acid. Linum Usitatissimum is
also the main source of secoisolariciresinol diglukoside
(SDG). Linum Usitatissimum have also anticancer,
antiviral, antibacterial and antifungal properties.
We planed to investigate the apoptotic effects of
secoisolariciresinol diglıcoside whic is the extract of
Linum Usitatissimum on cells of human colon carcinoma
cell lines CCL-228-SW - 480 in both two and three
dimensional culture conditions. In this context we
planned to investigate cell proliferation and cell death
cause of apoptosis.
We proved that the extract of Linum Usitatissimum
causes apoptosis on
effective dose with TUNEL, BrdU, AIF and Caspase-3
analysis on colon carcinoma cell lines. Because of two
and three dimensional culture our study is more
comprehensive than other studies. İt’s clearly understood
that Linum Usitatissimum’s extract, SDG, is beneficial to
in colon cancer. We think that our studies helpful to
further cancer studies. Also it will be beneficial for both
patients health and treatment costs.