Salivary Oxidative Variables Affect the Severity of Periodontal Disease in a Geriatric Population

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Işık A. R., Çelik S., Şirin F. B., Koşkan Ö., Yetkin Ay Z.

Journal of Geriatric Medicine and Gerontology, cilt.7, sa.1, ss.109, 2021 (Hakemli Dergi)

Özet

 Background: To evaluate the periodontal status and to investigate the possible role of some antimicrobial proteins and enzymes, and the oxidant/antioxidant balance in saliva of a geriatric population with different periodontal diseases. Assessments should be made about periodontal health, while preventive measures and treatment options/protocols should be developed for the elderly population in our country and in the world. Methods: Eighty participants aged ≥ 65 years were included and their periodontal parameters were recorded. The salivary samples of this population with gingivitis (Group 1, n = 21) and periodontitis (Stage III periodontitis (Group 2, n = 23), and Stage IV periodontitis (Group 3, n = 36)) were investigated regarding the presence and levels of some parameters (lysozyme, lactoferrin, lactoperoxidase (LPO), sIgA), and total oxidant and antioxidant status (TOS and TAS) were analyzed with ELISA. Results: Lactoferrin, sIgA, TOS, TAS, and OSI did not present statistically significant differences among the groups (P > 0.05). Lysozyme was similar in Group 1 and Group 2 (P > 0.05), but lower in both of these groups compared to Group 3 (P < 0.05). Linear discriminant factor function analysis revealed that salivary LPO, sIgA and TAS levels can discriminate the groups from each other. Strong correlations were found between lysozyme, LPO, and lactoferrin with periodontal parameters (p < 0.05). Conclusions: It can be argued that the oxidative mechanism plays a role in the progression and severity of periodontitis in the study population of the present study.


Keywords Elderly, Saliva, Lysozyme, Lactoferrin, Lactoperoxidase, Secretory immunoglobulin A, Oxidative stress