Evaluation of cognitive functions and EEG records in rats exposed to 2.45 GHz electromagnetic field

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Yücel H., Olgaç Dündar N., Kumbul Doğuç D., Uğuz A. C., Çelik Ö., Aksoy F. T., ...Daha Fazla

International Journal of Radiation Research, cilt.20, sa.4, ss.753-760, 2022 (SCI-Expanded)

Özet

Background: Electromagnetic fields may primarily affect cognitive functions. It has not

been elucidated how electromagnetic radiation affects the brain, particularly in the

young age group. We aimed to examine the cognitive function, expression of N-methyl

-D-aspartate receptors (NMDA), and EEG alterations in weaned rats exposed to a 2.45

GHz electromagnetic field. Materials and Methods: Twenty-one weaned (21 days old)

male Wistar Albino rats were divided into two groups as experimental group (n=12)

and control group (n=9). Animals in the experimental group were exposed to a 2.45

GHz electromagnetic field for one hour a day for more than 28 days. At the end of this

period, rats were subjected to training and learning test using Morris Water Maze.

After obtaining EEG records, hippocampi were removed. 2A and 2B subunits of NMDA

receptors were studied in hippocampal homogenates using the Western Blot method.

Results: There were no statistically significant differences between the two groups in

measures of latency to target quadrant, time spent in the target quadrant, and

average swim speed as compared in Morris water maze. However, the time to arrive

at the visible platform was significantly longer in experimental animals. There were no

statistically significant differences in expression of 2A and 2B subunits of NMDA

receptors between the two groups. Evaluation of EEG records revealed that spike

frequency was significantly higher and time to first spike was significantly shorter in

the experimental group. Conclusion: These results indicated that a 2.45 GHz

electromagnetic field might negatively affect EEG, motivation, and attention,

particularly in the young age group.