Protective effects of melatonin against oxidative injury in rat testis induced by wireless (2.45 GHz) devices

OKSAY T., NAZIROĞLU M., Dogan S., Guzel A., GÜMRAL N., Kosar P. A.

ANDROLOGIA, vol.46, no.1, pp.65-72, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1111/and.12044
  • Journal Name: ANDROLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.65-72
  • Keywords: Melatonin, oxidative stress, rat, testis, wireless devices, STRAND DNA BREAKS, VITAMIN-E, MICROWAVE-RADIATION, TESTICULAR FUNCTION, LIPID-PEROXIDATION, SOMATIC-CELLS, MOBILE PHONES, BRAIN CELLS, EXPOSURE, STRESS
  • Süleyman Demirel University Affiliated: Yes

Abstract

Wireless devices have become part of everyday life and mostly located near reproductive organs while they are in use. The present study was designed to determine the possible protective effects of melatonin on oxidative stress-dependent testis injury induced by 2.45-GHz electromagnetic radiation (EMR). Thirty-two rats were equally divided into four different groups, namely cage control (A1), sham control (A2), 2.45-GHz EMR (B) and 2.45-GHz EMR+melatonin (C). Group B and C were exposed to 2.45-GHz EMR during 60minday(-1) for 30days. Lipid peroxidation levels were higher in Group B than in Group A1 and A2. Melatonin treatment prevented the increase in the lipid peroxidation induced by EMR. Also reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) levels in Group D were higher than that of exposure group. Vitamin A and E concentrations decreased in exposure group, and melatonin prevented the decrease in vitamin E levels. In conclusion, wireless (2.45 GHz) EMR caused oxidative damage in testis by increasing the levels of lipid peroxidation and decreasing in vitamin A and E levels. Melatonin supplementation prevented oxidative damage induced by EMR and also supported the antioxidant redox system in the testis.