A primer on metabolic memory: why existing diabesity treatments fail

Copur S., Rossing P., AFŞAR B., Sag A. A. , Siriopol D., Kuwabara M., ...More

CLINICAL KIDNEY JOURNAL, vol.14, no.3, pp.756-767, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 14 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1093/ckj/sfaa143
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.756-767


Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.