A primer on metabolic memory: why existing diabesity treatments fail


Copur S., Rossing P., AFŞAR B. , Sag A. A. , Siriopol D., Kuwabara M., ...Daha Fazla

CLINICAL KIDNEY JOURNAL, cilt.14, sa.3, ss.756-767, 2021 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Konu: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1093/ckj/sfaa143
  • Dergi Adı: CLINICAL KIDNEY JOURNAL
  • Sayfa Sayıları: ss.756-767

Özet

Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.