A primer on metabolic memory: why existing diabesity treatments fail
CLINICAL KIDNEY JOURNAL, cilt.14, sa.3, ss.756-767, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 14 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.1093/ckj/sfaa143
- Dergi Adı: CLINICAL KIDNEY JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.756-767
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.