Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats

Oktem, F; Ozguner, F; Yilmaz, HR; Uz, Efkan; Dundar, B

doi:10.1111/j.1440-1681.2006.04330.x

Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats

Oktem F., Ozguner F., Yilmaz H., Uz E., Dundar B.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.33, ss.95-101, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 33
Basım Tarihi: 2006
Doi Numarası: 10.1111/j.1440-1681.2006.04330.x
Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.95-101
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

1. Increased oxidative stress has an important role in the pathogenesis of diabetic nephropathy. The aim of the present study was to evaluate diabetic nephropathy by determining markers of oxidative stress and the urinary excretion of N-acetyl-b-d-glucosaminidase (NAG), albumin and to investigate the possible protective effects of in vivo melatonin on renal tubular oxidative damage in diabetic rats.