Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.33, pp.95-101, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33
- Publication Date: 2006
- Doi Number: 10.1111/j.1440-1681.2006.04330.x
- Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.95-101
- Süleyman Demirel University Affiliated: Yes
Abstract
1. Increased oxidative stress has an important role in the pathogenesis of diabetic nephropathy. The aim of the present study was to evaluate diabetic nephropathy by determining markers of oxidative stress and the urinary excretion of N-acetyl-b-d-glucosaminidase (NAG), albumin and to investigate the possible protective effects of in vivo melatonin on renal tubular oxidative damage in diabetic rats.