Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats


Oktem F., Ozguner F., Yilmaz H., Uz E. , Dundar B.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.33, ss.95-101, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1440-1681.2006.04330.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Sayfa Sayıları: ss.95-101

Özet

1. Increased oxidative stress has an important role in the pathogenesis of diabetic nephropathy. The aim of the present study was to evaluate diabetic nephropathy by determining markers of oxidative stress and the urinary excretion of N-acetyl-b-d-glucosaminidase (NAG), albumin and to investigate the possible protective effects of in vivo melatonin on renal tubular oxidative damage in diabetic rats.