The effect of topical corticosteroid on basic fibroblast growth factor in nasal polyp tissue


Yariktas M., Doner F., Sutcu R., Demirci M., Dogru H., Yasan H.

AMERICAN JOURNAL OF RHINOLOGY, vol.19, no.3, pp.248-250, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1177/194589240501900306
  • Title of Journal : AMERICAN JOURNAL OF RHINOLOGY
  • Page Numbers: pp.248-250

Abstract

Background: The etiology of nasal polyposis and pathophysiological mechanisms of polyp formation is still poorly understood. Experimental models have suggested that nasal polyp growth requires extracellular matrix formation and is associated with fibroblast proliferation. Intranasal corticosteroids appear to be useful in reducing nasal polypoid lesions and the likelihood of polyp recurrence after surgery. Basic fibroblast growth factor (bFGF) is a potent angiogenesis factor and is mitogenic for a wide range of cell types. We investigated the alteration of bFGF levels in nasal polyp tissue after administration of topical corticosteroid.