Solubility studies of amlodipine besylate in ethylene glycol + ethanol mixtures at different temperatures
Indian Chemical Engineer, vol.66, no.2, pp.141-151, 2024 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 66 Issue: 2
- Publication Date: 2024
- Doi Number: 10.1080/00194506.2023.2280742
- Journal Name: Indian Chemical Engineer
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
- Page Numbers: pp.141-151
- Keywords: Amlodipine besylate, cosolvency models, solubility, thermodynamic parameters
- Süleyman Demirel University Affiliated: Yes
Abstract
In the current work, the solubility of amlodipine besylate (ADB) was studied in the ethylene glycol + ethanol at different temperatures (293.2-313.2 K). The experimental solubility data obtained herein were correlated with some well-known cosolvency models and the accuracy of these models was investigated with the mean relative deviations of the back calculated data. The apparent thermodynamic parameters (Gibbs energy, enthalpy and entropy) of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at Thm.