Febrile seizures comprise a common type of pediatric convulsion. Inflammation and genetics may be involved in their pathogenesis. Regarding the role of cytokines (especially interleukin-6) in febrile responses, we performed a case control study of interleukin-6 gene (-174, -572, and -597) single-nucleotide polymorphisms to learn if correlations existed between these particular polymorphisms and febrile seizures. We isolated the genomic DNA of 92 children with febrile seizures and 98 healthy control subjects. We genotyped individuals for their polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism. In our study, the frequencies of 174 G alleles and of the 174 and 572 GG genotypes were observed to be significantly higher in patients than in control subjects. The 174 GG genotype frequency was significantly higher in children with a family history of febrile seizures. (C) 2012 Elsevier Inc. All rights reserved.