Prevalence of Rotavirus-Associated Acute Gastroenteritis Cases in Early Childhood in Turkey: Meta-Analysis

Akpınar O. , Güzel M., Kılıç M. B.

CHILDREN-BASEL, vol.7, no.159, pp.1-12, 2020 (Journal Indexed in SCI)

  • Publication Type: Article / Article
  • Volume: 7 Issue: 159
  • Publication Date: 2020
  • Doi Number: 10.3390/children7100159
  • Title of Journal : CHILDREN-BASEL
  • Page Numbers: pp.1-12


Abstract: Background: Rotavirus is globally the most common viral pathogen in childhood

gastroenteritis. This study aimed to estimate the number of Turkish children su ering from

early-childhood gastroenteritis by rotavirus by performing a meta-analysis. Methods: Meta-analysis

following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)

guidelines was performed. Following the guidelines, primary studies were found reporting the

prevalence of rotavirus gastroenteritis in Turkey. We performed a computerized search of published

studies in national and international databases from 1990 to 2018. We selected 38 out of 721 studies

for our study. Meta-analysis was carried out using R statistical software. The Cochrane Q statistic

was calculated to assess the heterogeneity of the study results. Heterogeneity among studies was

evaluated using the I2 statistic. E ect-size estimate was reported with 95% confidence interval.

Results: On the basis of 38 selected articles, 80,113 children up to five years of age were diagnosed

with symptoms of acute gastroenteritis, of whom the stool samples of 13,651 children were positive

for rotavirus. The pooled prevalence of rotavirus was 19% in children younger than five years of age

with acute gastroenteritis. In terms of seasonal prevalence, the highest prevalence rate was found

in winter. Conclusion: This study supports the major prevalence of early-childhood gastroenteritis

by rotavirus among Turkish children. Therefore, the decision to adopt immunization programs to

prevent rotavirus infection might be helpful in Turkey.