Paroxetine is an antidepressant agent, which affects via selective inhibition of serotonin reuptake. It is widely used for the treatment of depression, obsessive compulsive disorder, panic disorder and anxiety disorder. Although it has low side effects and a high safety profile, some cases of severe toxic hepatitis associated with paroxetine have been reported. Hepatotoxicity can be hepatocellular, cholestatic or mixed type. It is generally idiosyncratic and unpredictable, however patients with high risk such as coexisting liver disease and use of other potential hepatotoxic drugs, should be monitored carefully for hepatotoxicity while using this drug. Here we report a case of severe toxic hepatitis related to use of paroxetine. The patient recoverd completely after the the drug was stopped.