Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha E., White J. R. , Yu S., Kulac I., Ertunc O. , De Marzo A. M. , ...More

JOURNAL OF UROLOGY, vol.199, no.1, pp.161-171, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 199 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1016/j.juro.2017.08.001
  • Title of Journal : JOURNAL OF UROLOGY
  • Page Numbers: pp.161-171
  • Keywords: prostatic neoplasms, urinary tract, microbiota, inflammation, bacteria, PROPIONIBACTERIUM-ACNES, INFLAMMATION, PATHOGENESIS, INFECTIONS, TISSUE

Abstract

Purpose: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. Therefore, we profiled the urinary microbiome in men with positive vs negative biopsies for prostate cancer.