Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha, Eva; White, James; Yu, Shu-Han; Kulac, Ibrahim; Ertunc, Onur; De Marzo, Angelo; Yegnasubramanian, Srinivasan; Mangold, Leslie; Partin, Alan; Sfanos, Karen

doi:10.1016/j.juro.2017.08.001

Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha E., White J. R. , Yu S., Kulac I., Ertunc O. , De Marzo A. M. , ...More

JOURNAL OF UROLOGY, vol.199, no.1, pp.161-171, 2018 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 199 Issue: 1
Publication Date: 2018
Doi Number: 10.1016/j.juro.2017.08.001
Title of Journal : JOURNAL OF UROLOGY
Page Numbers: pp.161-171

Abstract

Purpose: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. Therefore, we profiled the urinary microbiome in men with positive vs negative biopsies for prostate cancer.