Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer
JOURNAL OF UROLOGY, vol.199, no.1, pp.161-171, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 199 Issue: 1
- Publication Date: 2018
- Doi Number: 10.1016/j.juro.2017.08.001
- Journal Name: JOURNAL OF UROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.161-171
- Keywords: prostatic neoplasms, urinary tract, microbiota, inflammation, bacteria, PROPIONIBACTERIUM-ACNES, INFLAMMATION, PATHOGENESIS, INFECTIONS, TISSUE
- Süleyman Demirel University Affiliated: No
Abstract
Purpose: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. Therefore, we profiled the urinary microbiome in men with positive vs negative biopsies for prostate cancer.