Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer
JOURNAL OF UROLOGY, cilt.199, sa.1, ss.161-171, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 199 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.1016/j.juro.2017.08.001
- Dergi Adı: JOURNAL OF UROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.161-171
- Anahtar Kelimeler: prostatic neoplasms, urinary tract, microbiota, inflammation, bacteria, PROPIONIBACTERIUM-ACNES, INFLAMMATION, PATHOGENESIS, INFECTIONS, TISSUE
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Purpose: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. Therefore, we profiled the urinary microbiome in men with positive vs negative biopsies for prostate cancer.