Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha E., White J. R. , Yu S., Kulac I., Ertunc O. , De Marzo A. M. , ...Daha Fazla

JOURNAL OF UROLOGY, cilt.199, sa.1, ss.161-171, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 199 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.juro.2017.08.001
  • Dergi Adı: JOURNAL OF UROLOGY
  • Sayfa Sayıları: ss.161-171

Özet

Purpose: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. Therefore, we profiled the urinary microbiome in men with positive vs negative biopsies for prostate cancer.