Secondary Cutaneous Dissemination of Peripheral T-Cell Lymphoma With T-Follicular Helper Phenotype as a Patient's Fourth Primary Malignancy
AMERICAN JOURNAL OF DERMATOPATHOLOGY, vol.41, no.10, pp.754-756, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 41 Issue: 10
- Publication Date: 2019
- Doi Number: 10.1097/dad.0000000000001420
- Journal Name: AMERICAN JOURNAL OF DERMATOPATHOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.754-756
- Süleyman Demirel University Affiliated: No
Abstract
Peripheral T-cell lymphomas expressing follicular helper T-cell (T-FH) markers have recently been identified. Although this type of lymphomas consist of malignant proliferation of T-cells, they may also exhibit B-cell clonality. We report a case of a 72-year-old woman with multiple erythematous to violaceous nonscaling plaques and tumors on her trunk. Histopathological analysis revealed a dense infiltration of medium-to-large-sized atypical cells throughout the entire dermis. The result of immunohistochemical analysis showed that the infiltrating T-cells expressed programmed death-1 (PD-1), CD10, Bcl-6, CD3, CD4, CD2, and CD5. The infiltrate also contained scattered atypical large B-cells. Based on the clinical appearance and the histopathological findings, we diagnosed the patient with secondary cutaneous dissemination of peripheral T-cell lymphoma with expression of a T-follicular helper phenotype.