Is nitric oxide involved in the pathophysiology of essential hyperhidrosis?

Karaca S., Kulac M., Uz E. , Barutcu I., Yilmaz H. R.

INTERNATIONAL JOURNAL OF DERMATOLOGY, vol.46, no.10, pp.1027-1030, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1365-4632.2007.03243.x
  • Title of Journal : INTERNATIONAL JOURNAL OF DERMATOLOGY
  • Page Numbers: pp.1027-1030

Abstract

Background Essential hyperhidrosis (EH) is a disorder of excessive, bilateral, and relatively symmetric sweating occurring in the axillae, palms, soles, or craniofacial region without obvious etiology. The expression of endothelial nitric oxide synthase (eNOS) in eccrine clear cells, reported by an immunohistochemical technique, has suggested that nitric oxide (NO) may play a role in the physiology of production and/or excretion of sweat in the human skin eccrine gland.