Although die casting is a near net shape manufacturing process, it mainly involves a thermal process. Therefore, in order to produce high quality parts, it is important to determine casting-mold interfacial heat transfer coefficient and heat flux. In this paper the effects of different injection parameters (second phase velocity, injection pressure, pouring and die temperature) on heat flux and interfacial heat transfer coefficient were investigated experimentally and numerically. Experiments were performed in cylindrical geometry using a cast aluminum alloy A360 against H13 steel mold. Selected injection parameters were 1.7-2.5 m/s for second phase velocity, 100-200 bar for third phase pressure, 983-1053 K for pouring temperature and 373, 433, 493, 553 K for the die temperature. These parameters were used for both non-vacuum and vacuum conditions in the cavity of the mold. The effects of the application under vacuum conditions were also studied. Temperatures were measured as functions of time, using 18 thermocouples, which were mounted at different depths of casting and mold material. Measured and calculated temperature values are found compatible. Interfacial heat transfer coefficient h and heat flux q depending on the experimentally measured temperature values were calculated with finite difference method using explicit technique in C# programming language. In addition to experiments, Flow-3D software simulations were performed using the same parameters. Interfacial heat transfer coefficient and heat flux results obtained from Flow-3D are also presented in the study. Interfacial heat transfer coefficient has decreased as a result of increasing of temperature of mold and pouring. In addition, interfacial heat transfer coefficient values have increased slightly with the increase of injection speed and pressure. It was observed that the values of interfacial heat transfer coefficient and heat flux have also increased when vacuum was applied inside the cavity of the mold. When all injection parameters are considered, it is seen that the interfacial heat transfer coefficient varies between 92-117 kW/m(2)K.