Catecholase-Like Activity Studies of Tc-99m Radiopharmaceuticals
ACTA PHYSICA POLONICA A, vol.129, no.2, pp.213-215, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 129 Issue: 2
- Publication Date: 2016
- Doi Number: 10.12693/aphyspola.129.213
- Journal Name: ACTA PHYSICA POLONICA A
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.213-215
- Süleyman Demirel University Affiliated: Yes
Abstract
Catechol oxidase catalyses the oxidation of a broad range of catechols to the corresponding o-quinones through the four-electron reduction of molecular oxygen to water, without acting on tyrosine. The resulting highly reactive quinones autopolymerize to form brown polyphenolic catechol melanins, a process thought to protect the damaged plant against pathogens or insects. This work describes the catalytic activity of some radiopharmaceuticals like Tc-99m pertechnetate, Tc-99m mercaptoacetyltriglycine (MAG3), Tc-99m nanocolloid, Tc-99m methylenebis(phosphonic acid) (MDP) and Tc-99m methoxyisobutylisonitrile (MIBI) for oxidation of catechol. The catalytic oxidation of 3,5-di-tert-butylcatechol by selected radiopharmaceuticals saturated with molecular oxygen was studied in a homogeneous system. All the radiopharmaceuticals exhibited catecholase-like activity.