Catecholase-Like Activity Studies of Tc-99m Radiopharmaceuticals


Cicek E., DEDE B.

ACTA PHYSICA POLONICA A, vol.129, no.2, pp.213-215, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 129 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.12693/aphyspola.129.213
  • Title of Journal : ACTA PHYSICA POLONICA A
  • Page Numbers: pp.213-215

Abstract

Catechol oxidase catalyses the oxidation of a broad range of catechols to the corresponding o-quinones through the four-electron reduction of molecular oxygen to water, without acting on tyrosine. The resulting highly reactive quinones autopolymerize to form brown polyphenolic catechol melanins, a process thought to protect the damaged plant against pathogens or insects. This work describes the catalytic activity of some radiopharmaceuticals like Tc-99m pertechnetate, Tc-99m mercaptoacetyltriglycine (MAG3), Tc-99m nanocolloid, Tc-99m methylenebis(phosphonic acid) (MDP) and Tc-99m methoxyisobutylisonitrile (MIBI) for oxidation of catechol. The catalytic oxidation of 3,5-di-tert-butylcatechol by selected radiopharmaceuticals saturated with molecular oxygen was studied in a homogeneous system. All the radiopharmaceuticals exhibited catecholase-like activity.