Histoprotective Effect of Resveratrol and Avocado Oil Against Acetaminophen Related Acute Nephrotoxicity in Rats


Yeşilot Ş., Özgöçmen M. , Acar Ç. A.

X. National and I. International Veterinary Pathology Congress, Burdur, Turkey, 27 - 31 October 2020, pp.93

  • Publication Type: Conference Paper / Summary Text
  • City: Burdur
  • Country: Turkey
  • Page Numbers: pp.93

Abstract

Acetaminophen has an acceptable safety profile when used in prescribed doses, however, it can damage the kidneys when administered as an overdose. This study was designed to investigate the tissue repair effects of Resveratrol and Avocado oil on acetamiophen-induced acute nephrotoxicity in rats. 30 male Wistar rats approximately 500 gr were used randomly divided into 5 groups, each containing 6 rats: Group I = Control; Group II = Acetaminophen (600 mg/kg i.p;single dose); Group III =  Acetaminophen+Resveratrol (10 mg/kg/po Resveratrol, for 4 days); Group IV = Acetaminophen+Avocado Oil (200mg/kg/po Avocado Oil, for 4 days); Group V = Acetaminophen + Resveratrol + Avocado Oil (combination treatment with Resveratrol and Avocado Oil doses). At the end of the experiment, renal tissue samples were collected for histopathological examinations. Kidney tissues were stained with hematoxylin and eosin for histological assessment. Significant histopathological changes including tubular vacuoler degeneration, tubular dilatation, cortical and medullar haemorrhage, mononuclear cell infiltration were observed in the Group II. Renal histopathological examinations showed that Resveratrol administration significantly reduced Acetaminophen induced renal damage. However, Avocado Oil is ineffective. In conclusion, it is thought that the use of Resveratrol as a prophylactic agent against renal damage may be beneficial. Keywords: Acetaminophen, resveratrol, avocado oil, nephrotoxicity