Research Information System
X. National and I. International Veterinary Pathology Congress, Burdur, Turkey, 27 - 31 October 2020, pp.93
Acetaminophen has an acceptable safety profile when used in prescribed doses, however, it can
damage the kidneys when administered as an overdose. This study was designed to investigate
the tissue repair effects of Resveratrol and Avocado oil on acetamiophen-induced acute
nephrotoxicity in rats. 30 male Wistar rats approximately 500 gr were used randomly divided
into 5 groups, each containing 6 rats: Group I = Control; Group II = Acetaminophen (600 mg/kg
i.p;single dose); Group III = Acetaminophen+Resveratrol (10 mg/kg/po Resveratrol, for 4
days); Group IV = Acetaminophen+Avocado Oil (200mg/kg/po Avocado Oil, for 4 days);
Group V = Acetaminophen + Resveratrol + Avocado Oil (combination treatment with
Resveratrol and Avocado Oil doses). At the end of the experiment, renal tissue samples were
collected for histopathological examinations. Kidney tissues were stained with hematoxylin and
eosin for histological assessment. Significant histopathological changes including tubular
vacuoler degeneration, tubular dilatation, cortical and medullar haemorrhage, mononuclear cell
infiltration were observed in the Group II. Renal histopathological examinations showed that
Resveratrol administration significantly reduced Acetaminophen induced renal damage.
However, Avocado Oil is ineffective. In conclusion, it is thought that the use of Resveratrol as
a prophylactic agent against renal damage may be beneficial.
Keywords: Acetaminophen, resveratrol, avocado oil, nephrotoxicity