Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder

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Aydoğan Avşar P., Işık Ü. , Aktepe E., Kılıç F. , Doğuç D. , Büyükbayram H.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2020
  • Doi Number: 10.1080/13651501.2020.1801754
  • Keywords: Attention-deficit, hyperactivity disorder, blood-brain barrier, claudin-5, intestinal permeability, zonulin, BLOOD-BRAIN-BARRIER, INTESTINAL PERMEABILITY, GUT PERMEABILITY, TIGHT JUNCTIONS, UP-REGULATION, HYPERACTIVITY, PATHOGENESIS, DYSFUNCTION, EXPRESSION, PATHOLOGY


Objective This study aimed to investigate serum zonulin and claudin-5 levels of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls by controlling the parameters such as age, sex and body mass index (BMI) percentile which are known to affect these parameters. Method A total of 80 treatment-naive children and adolescents with ADHD and 40 healthy volunteer controls aged 8-12 years were enrolled in this study. The severities of ADHD symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were assessed by the self-report inventories. Serum levels of zonulin and claudin-5 were measured using commercial enzyme-linked immunosorbent assay kits. Results The multivariate analysis of covariance (MANCOVA) revealed a significant main effect of groups in the serum zonulin and claudin-5 levels, an effect that was independent of age, sex and BMI percentile. Significant differences were found between the study groups in terms of serum log-claudin-5 levels. However, there was no significant difference between the study groups in terms of serum zonulin levels Conclusion These findings provide additional evidence for dysregulation of the blood-brain barrier, especially abnormalities in claudin-5 function, which may be involved in the aetiology of ADHD.