Effect of bencyclane fumarate on intestinal ischaemia reperfusion injury


BARUT İ. , TARHAN Ö. R. , KAPUCUOGLU N., SUTCU R., AKDENIZ Y.

ANZ JOURNAL OF SURGERY, vol.78, no.6, pp.476-481, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1445-2197.2008.04358.x
  • Title of Journal : ANZ JOURNAL OF SURGERY
  • Page Numbers: pp.476-481

Abstract

Background: Post-ischaemic intestinal tissue damage appears to be due to the formation of oxygen radicals. Free radical-initiated lipid peroxidation following intestinal ischaemia/reperfusion (I/R) may disrupt mucosal integrity. Indirectly, the radicals trigger the accumulation of neutrophils within the affected tissue, initiating inflammatory processes that lead to severe mucosal lesions. We have investigated the protective effect of bencyclane fumarate, a vasodilating Ca(2+) channel blocker, which has been used for the treatment of peripheral arterial occlusive diseases, on intestinal ischaemia reperfusion (IR) injury in rats.