Synthesis of 3-Substitued-5-Chloro-2-(3H)-Benzothiazolone Derivatives
8th Drug Chemistry Conference, Antalya, Türkiye, 27 Şubat - 01 Mart 2020, ss.110, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Antalya
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.110
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
In the 21th century, many drug targets have been investigated intensely and therefore it is necessary
to find new drug substances for new targets. 2-(3H)-Benzothiazolone derivatives have a potential for
phamaceutical industry. The ring can be substitued on diverse positions and chemists can obtain
different new derivatives. In the literature, it has been reported that various derivatives of the 3-
substituted 2-(3H)-benzothiazolones have been obtained and these have high antimicrobial1
,
antiviral1
, antinociceptive2
, analgesic3
, antiinflamatory3
, and anticonvulsan4
activities as well as high
affinity to serotonin receptors5
. Based on this information, we designed some amide derivatives
bearing 5-chloro-2-(3H)-benzothiazolone ring and these were synthesized in three steps and finally the
structure of the substances are verified analyzing NMR spectra and purity was controlled using LC-MS.
Later, we will evaluate their biological activities.