Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of patients with schizophrenia: a case-control study


Unal G. O. , Ozturk K. H. , İNCİ H. E.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1080/13651501.2022.2106245
  • Journal Name: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Psycinfo
  • Keywords: Schizophrenia, NLRP3, P2X7R, inflammasome, IL-1 beta, IL-18, SYMPTOMS, RECEPTOR, ASSOCIATION, INVOLVEMENT, ACTIVATION, DISORDERS, PATHWAY, RISK

Abstract

Objective: This study aimed to evaluate the gene expression of the P2X purinoceptor 7 (P2X7R)- nod-like receptor pyrin domain-containing protein 3 (NLRP3) signal pathway in peripheral blood mononuclear cells (PBMCs) between schizophrenia (SCZ) patients and healthy controls (HC) to reveal its relationship with clinical variables.