Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of patients with schizophrenia: a case-control study
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, vol.27, no.2, pp.111-117, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27 Issue: 2
- Publication Date: 2023
- Doi Number: 10.1080/13651501.2022.2106245
- Journal Name: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Psycinfo
- Page Numbers: pp.111-117
- Keywords: Schizophrenia, NLRP3, P2X7R, inflammasome, IL-1 beta, IL-18, ANTIINFLAMMATORY AGENTS, SYMPTOMS, RECEPTOR, ASSOCIATION, INVOLVEMENT, ACTIVATION, DISORDERS, PATHWAY, RISK
- Süleyman Demirel University Affiliated: Yes
Abstract
Objective: This study aimed to evaluate the gene expression of the P2X purinoceptor 7 (P2X7R)- nod-like receptor pyrin domain-containing protein 3 (NLRP3) signal pathway in peripheral blood mononuclear cells (PBMCs) between schizophrenia (SCZ) patients and healthy controls (HC) to reveal its relationship with clinical variables.