A study on 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones


ALKAN M., YUEKSEK H., İSLAMOĞLU F., BAHÇECİ S., Calapoglu M. , ELMASTAŞ M., ...Daha Fazla

MOLECULES, cilt.12, ss.1805-1816, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 12 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.3390/12081805
  • Dergi Adı: MOLECULES
  • Sayfa Sayıları: ss.1805-1816

Özet

Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, (HNMR)-H-1, C-13-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pK(a) values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(p-methoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.