Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?

Yigit U., KIRZIOĞLU F. Y. , Uguz A. C. , NAZIROĞLU M. , Ozmen O.

ARCHIVES OF ORAL BIOLOGY, cilt.81, ss.61-68, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Background and objectives: Host modulation therapies (anti-inflammatory drugs, bone-stimulating agents, antiproteinase etc.) target the inhibition or stabilization of tissue breakdown. The aim of the present study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) and/or low dose doxycycline (LDD) administrations on alveolar bone loss (ABL), serum cytokines and gingival apoptosis, as well as the levels of oxidants and antioxidants in rats with ligature-induced periodontitis.