Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?

Yigit U., KIRZIOĞLU F. Y., Uguz A. C., NAZIROĞLU M., Ozmen O.

ARCHIVES OF ORAL BIOLOGY, vol.81, pp.61-68, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81
  • Publication Date: 2017
  • Doi Number: 10.1016/j.archoralbio.2017.04.017
  • Journal Name: ARCHIVES OF ORAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.61-68
  • Keywords: Caffeic acid phenethyl ester-CAPE, Doxycycline, Periodontitis, Cytokines, Oxidative stress, Apoptosis, ALVEOLAR BONE LOSS, NECROSIS-FACTOR-ALPHA, LOW-DOSE DOXYCYCLINE, FACTOR-KAPPA-B, ISCHEMIA/REPERFUSION INJURY, OXIDATIVE DAMAGE, RATS, APOPTOSIS, DISEASE, MODEL
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background and objectives: Host modulation therapies (anti-inflammatory drugs, bone-stimulating agents, antiproteinase etc.) target the inhibition or stabilization of tissue breakdown. The aim of the present study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) and/or low dose doxycycline (LDD) administrations on alveolar bone loss (ABL), serum cytokines and gingival apoptosis, as well as the levels of oxidants and antioxidants in rats with ligature-induced periodontitis.