Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?

Yigit U., KIRZIOĞLU F. Y. , Uguz A. C. , NAZIROĞLU M. , Ozmen O.

ARCHIVES OF ORAL BIOLOGY, vol.81, pp.61-68, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81
  • Publication Date: 2017
  • Doi Number: 10.1016/j.archoralbio.2017.04.017
  • Title of Journal : ARCHIVES OF ORAL BIOLOGY
  • Page Numbers: pp.61-68


Background and objectives: Host modulation therapies (anti-inflammatory drugs, bone-stimulating agents, antiproteinase etc.) target the inhibition or stabilization of tissue breakdown. The aim of the present study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) and/or low dose doxycycline (LDD) administrations on alveolar bone loss (ABL), serum cytokines and gingival apoptosis, as well as the levels of oxidants and antioxidants in rats with ligature-induced periodontitis.