Effects of Pentoxifylline on Amikacin-Induced Nephrotoxicity in Rats
RENAL FAILURE, cilt.31, sa.2, ss.134-139, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2009
- Doi Numarası: 10.1080/08860220802595492
- Dergi Adı: RENAL FAILURE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.134-139
- Anahtar Kelimeler: amikacin, renal injury, pentoxifylline, rat, TUMOR-NECROSIS-FACTOR, ACUTE-RENAL-FAILURE, FACTOR-ALPHA, PHOSPHODIESTERASE ISOZYMES, DIABETIC-PATIENTS, INHIBITORS, SUPPRESSION, GLOMERULONEPHRITIS, ANTIOXIDANT, DERIVATIVES
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to determine renal malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine (Cr) levels. MDA production was found to be higher in AK group. PTX administration caused a significant decrease in MDA production. Morphological damage in rats given AK was severe in the kidney, whereas in rats given AK plus PTX, no histological changes occurred. It is concluded that PTX could be useful for reducing the nephrotoxic effects of AK.