DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, cilt.825, ss.15-18, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 825
- Basım Tarihi: 2018
- Doi Numarası: 10.1016/j.mrgentox.2017.11.002
- Dergi Adı: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.15-18
- Anahtar Kelimeler: Silybum marianum, Silmarin, Comet assay, COMET ASSAY, OXIDATIVE STRESS, INDIVIDUAL CELLS, IN-VITRO, ANTIOXIDANT, MELLITUS, SILYBIN, REPAIR, HYPERGLYCEMIA, BIOMARKERS
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.