DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin


TOĞAY V. A. , SEVIMLI T. S. , SEVİMLİ M. , Celik D. A. , ÖZÇELİK N.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, cilt.825, ss.15-18, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 825
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.mrgentox.2017.11.002
  • Dergi Adı: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
  • Sayfa Sayısı: ss.15-18

Özet

Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.