DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin


TOĞAY V. A. , SEVIMLI T. S. , SEVİMLİ M., Celik D. A. , ÖZÇELİK N.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, vol.825, pp.15-18, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 825
  • Publication Date: 2018
  • Doi Number: 10.1016/j.mrgentox.2017.11.002
  • Journal Name: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.15-18
  • Keywords: Silybum marianum, Silmarin, Comet assay, COMET ASSAY, OXIDATIVE STRESS, INDIVIDUAL CELLS, IN-VITRO, ANTIOXIDANT, MELLITUS, SILYBIN, REPAIR, HYPERGLYCEMIA, BIOMARKERS
  • Süleyman Demirel University Affiliated: Yes

Abstract

Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.