Effects of ischemia-reperfusion on NMDA receptor subunits 2A and 2B level in rat hippocampus


Sutcu R., Altuntas I., Eroglu E., Delibas N.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.115, no.3, pp.305-314, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 115 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1080/00207450590519012
  • Journal Name: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.305-314
  • Süleyman Demirel University Affiliated: No

Abstract

The authors investigated the effects of ischemia and reperfusion on the N-methyl-D-aspartate receptor (NMDAR) subunits 2A and 2B concentration in rat hippocampus. At the protein level, significant increase in the amounts of NMDAR 2A and NMIDAR 2B in the rat hippocampus was observed at 1 h after reperfusion compared with control group. These results suggested that the alteration in hippocampal NMDAR2 subunit concentrations after ischemia-reperfusion might be involved in cognitive dysfunction and excitotoxicity.