Antioxidant Potential and Inhibition of Key Enzymes Linked to Alzheimer's Diseases and Diabetes Mellitus by Monoterpene-Rich Essential Oil from Sideritis galatica Bornm. Endemic to Turkey

Zengin G., Sarikurkcu C., Aktumsek A., Ceylan R.

RECORDS OF NATURAL PRODUCTS, vol.10, no.2, pp.195-206, 2016 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2016
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.195-206
  • Süleyman Demirel University Affiliated: Yes


The present study was designated to (1) characterize the essential oil from S. galatica (SGEOs) and (2) evaluate its antioxidant and enzyme inhibitory activities. Antioxidant capacity was tested different methods including free radical scavenging (DPPH, ABTS and NO), reducing power (FRAP and CUPRAC), metal chelating and phosphomolybdenum. Inhibitory activities were analyzed on acetylcholiesterase, butrylcholinesterase, alpha-amylase and alpha-glucosidase. SGEOs were chemically analyzed and identified by gas chromatography and gas chromatography/mass spectrophotometry. 23 components, representing 98.1% of SGEOs were identified. Monoterpene hydrocarbons (74.1%), especially alpha-(23.0%) and beta-pinene (32.2%), were the main constituents in SGEOs. The main sesquiterpene hydrocarbons were beta-caryophyllene (16.9%), germacrene-D (1.2%) and caryophyllene oxide (1.2%), respectively. Generally, SGEOs has shown moderate free radical, reducing power, metal chelating and enzyme inhibitory activities. These activities related to chemical profile in SGEOs. Our findings supported that the possible utility of SGEOs is a source of natural agents for food or pharmaceutical industries.