Solubility Study of Amlodipine Besylate in Ethylene Glycol + 2-Propanol Mixtures at Different Temperatures
Moscow University Chemistry Bulletin, cilt.79, sa.1, ss.72-78, 2024 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 79 Sayı: 1
- Basım Tarihi: 2024
- Doi Numarası: 10.3103/s0027131424010048
- Dergi Adı: Moscow University Chemistry Bulletin
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.72-78
- Anahtar Kelimeler: amlodipine besylate, cosolvency models, solubility
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Abstract: Solubility behavior of amlodipine besylate (ADB) was investigated in the binary mixtures of ethylene glycol + 2-propanol at five different temperatures (293.2–313.2 K). The solubility results obtained from the shake-flask method are correlated with some reported cosolvency models (i.e. the van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, the mixture response surface, the modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models is investigated with the mean relative deviations of the back-calculated solubility data.