Solubility Study of Amlodipine Besylate in Ethylene Glycol + 2-Propanol Mixtures at Different Temperatures
Moscow University Chemistry Bulletin, vol.79, no.1, pp.72-78, 2024 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 79 Issue: 1
- Publication Date: 2024
- Doi Number: 10.3103/s0027131424010048
- Journal Name: Moscow University Chemistry Bulletin
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, Veterinary Science Database
- Page Numbers: pp.72-78
- Keywords: amlodipine besylate, cosolvency models, solubility
- Süleyman Demirel University Affiliated: Yes
Abstract
Abstract: Solubility behavior of amlodipine besylate (ADB) was investigated in the binary mixtures of ethylene glycol + 2-propanol at five different temperatures (293.2–313.2 K). The solubility results obtained from the shake-flask method are correlated with some reported cosolvency models (i.e. the van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, the mixture response surface, the modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models is investigated with the mean relative deviations of the back-calculated solubility data.