BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, vol.8, no.1, pp.262-267, 2017 (ESCI)
- Publication Type: Article / Article
- Volume: 8 Issue: 1
- Publication Date: 2017
- Doi Number: 10.13040/ijpsr.0975-8232.8(1).262-67
- Journal Name: INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
- Journal Indexes: Emerging Sources Citation Index (ESCI)
- Page Numbers: pp.262-267
- Süleyman Demirel University Affiliated: No
Abstract
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C. albicans.