Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma


Suren D., Yildirim M., KAYA V. , Alikanoglu A. S. , Bulbuller N., Yildiz M., ...More

MEDICAL SCIENCE MONITOR, vol.20, pp.1255-1262, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2014
  • Doi Number: 10.12659/msm.890598
  • Title of Journal : MEDICAL SCIENCE MONITOR
  • Page Numbers: pp.1255-1262

Abstract

Background: Tight junction proteins in the cell organize paracellular permeability and they play a critical role in apical cell-to-cell adhesion and epithelial polarity. Claudins are major integral membrane proteins of tight junctions, especially Claudin 1, 4, and 7, which are known as the impermeability Claudins. In this study, we investigated the importance of loss of Claudin 1, 4, and 7 expression, and their relation to tumor progression in colorectal cancer patients.