In this study, thermodynamic analysis of heat pump system for residential heating is analyzed for alternative refrigerants for Isparta conditions. For this aim, the refrigerants are selected to be R22, R404A, R410A, R407C, R134A and R600. Using the thermodynamic properties of these refrigerants, performance parameters of the system such as COP, exergy efficiency and irreversibility rates are calculated. From the results the best refrigerant is found to be R600, followed by R22 and R134A. Additionally, a parametric study is carried out to determine how COP, exergy efficiency and irreversibility rate of the system vary with different condenser and evaporator temperatures.