Prevalence of Celiac Disease, Non-Celiac Gluten Sensitivity, and Wheat Allergy in Siblings of Children with Celiac Disease: Cross-Sectional Prospective Study Çölyak Hastaliǧi Olan Çocuklarin Kardeşlerinde Çölyak Hastaliǧi, Çölyak Dişi Gluten Duyarliliǧi ve Buǧday Alerjisi Sikliǧi: Kesitsel Prospektif Çalisma


Turkiye Klinikleri Pediatri, vol.31, no.2, pp.101-105, 2022 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5336/pediatr.2022-88157
  • Journal Name: Turkiye Klinikleri Pediatri
  • Journal Indexes: Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.101-105
  • Keywords: Celiac disease, gluten sensitivity, wheat allergy
  • Süleyman Demirel University Affiliated: No


Copyright © 2022 by Türkiye Klinikleri.Objective: Celiac disease (CD) is an autoimmune-mediated disease characterized by small intestinal mucosal damage after gluten exposure in genetically predisposed individuals. Although it is known that the prevalence of CD in siblings of celiac patients is more common than the normal population, there are limited studies on the frequency of non-celiac gluten sensitivity (NCGS) and wheat allergy (WA). In this study, we aimed to investigate the prevalence of CD, NCGS and WA in siblings of children with CD. Material and Methods: Siblings of patients diagnosed with CD in our pediatric gastroenterology clinic were examined for CD, NCGS and WA. CD diagnosed according to The European Society for Paediatric Gastroenterology Hepatology and Nutrition guideline. NCGS was diagnosed with the disappearance of symptoms related to gluten intake with gluten elimination, while WA was diagnosed with the absence of wheat-related symptoms after wheat removal from the diet and wheat-specific immunoglobulin E assays. Demographic and clinical features and laboratory parameters of the cases were recorded. Results: 50 siblings of 59 celiac patients eligible for the study [25 males (50%), mean age±standard deviation; 11.5±3.66 years (4-17 years)] were included. Three of the siblings [6%, 95% confidence interval (CI): 1.56-17.54) were diagnosed with CD, and 7 (14%, 95% CI: 6.28-27.36) were diagnosed with NCGS. There was no sibling with a diagnosis of WA. Conclusion: In our study, both CD and NCGS were found to have a higher prevalence in siblings of CD patients. When screening siblings of patients with CD, cases with symptoms and normal serology and endoscopy findings should be evaluated for NCGS.