Comparison of Serum VEGF, IGF-1, and HIF-1 alpha Levels in Children with Autism Spectrum Disorder and Healthy Controls

Creative Commons License

Şimşek F., Işık Ü., Aktepe E., Kılıç F., Şirin F. B., Bozkurt M.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, vol.51, no.10, pp.3564-3574, 2021 (SSCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.1007/s10803-020-04820-w
  • Journal Name: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, BIOSIS, Child Development & Adolescent Studies, CINAHL, EBSCO Education Source, Education Abstracts, Educational research abstracts (ERA), EMBASE, ERIC (Education Resources Information Center), Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo, Public Affairs Index
  • Page Numbers: pp.3564-3574
  • Keywords: Autism spectrum disorder, HIF-1&#945, IGF-1, VEGF, ENDOTHELIAL GROWTH-FACTOR, INDUCIBLE FACTOR-I, TUMOR-NECROSIS-FACTOR, ABERRANT BEHAVIOR CHECKLIST, CEREBROSPINAL-FLUID, FACTOR-ALPHA, FACTOR 1-ALPHA, RATING-SCALE, INSULIN, FACTOR-1-ALPHA
  • Süleyman Demirel University Affiliated: Yes

Abstract

The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1 alpha levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1 alpha were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1 alpha levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1 alpha may play a potential role in the etiopathogenesis of ASD.