JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, vol.51, no.10, pp.3564-3574, 2021 (SSCI)
Article / Article
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, BIOSIS, Child Development & Adolescent Studies, CINAHL, EBSCO Education Source, Education Abstracts, Educational research abstracts (ERA), EMBASE, ERIC (Education Resources Information Center), Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo, Public Affairs Index
Autism spectrum disorder, HIF-1α, IGF-1, VEGF, ENDOTHELIAL GROWTH-FACTOR, INDUCIBLE FACTOR-I, TUMOR-NECROSIS-FACTOR, ABERRANT BEHAVIOR CHECKLIST, CEREBROSPINAL-FLUID, FACTOR-ALPHA, FACTOR 1-ALPHA, RATING-SCALE, INSULIN, FACTOR-1-ALPHA
Süleyman Demirel University Affiliated:
The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1 alpha levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1 alpha were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1 alpha levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1 alpha may play a potential role in the etiopathogenesis of ASD.