N-functionalized benzimidazol-2-ylidene silver complexes: synthesis, characterization, and antimicrobial studies


GÖK Y., Akkoc S., Ozeroglu Celikal O., ÖZDEMİR İ., GÜNAL S., Sayin E.

TURKISH JOURNAL OF CHEMISTRY, vol.37, no.6, pp.1007-1013, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.3906/kim-1304-72
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1007-1013
  • Keywords: N-Heterocyclic carbene, benzimidazol-2-ylidene, silver complex, antimicrobial activity, medical inorganic chemistry, CARBENE COMPLEXES, PALLADIUM, ACTIVATION, COPPER
  • Süleyman Demirel University Affiliated: No

Abstract

2-Methoxyethyl, 2-diethylaminoethyl, and 2-phenylethyl-substituted N-heterocyclic carbene (NHC) precursors were treated with Ag2CO3 to yield silver(I)-NHC complexes (1a-g) in dichloromethane as a solvent at room temperature. The 7 new silver-NHC complexes were fully characterized by means of H-1 NMR, C-13 NMR, and elemental analysis techniques. Using the agar dilution procedure recommended by the Laboratory and Clinical Standards Institute, the antimicrobial activities of all the silver-NHC complexes were studied against 2 gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli), 2 gram-positive bacterial strains (Enterococcus faecalis and Staphylococcus aureus), and 2 fungi (Candida tropicalis and Candida albicans).