CLEFT PALATE-CRANIOFACIAL JOURNAL, 2021 (Peer-Reviewed Journal)
Article / Article
CLEFT PALATE-CRANIOFACIAL JOURNAL
Science Citation Index Expanded, Scopus, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Veterinary Science Database
ALX gene, cleft lip, cleft palate, facial clefts, frontonasal dysplasia, hypertelorism, median cleft, CNS STRUCTURAL ANOMALIES, MENTAL-RETARDATION, EYELID COLOBOMAS, EAR ANOMALIES, MACROBLEPHARON, HYPERTELORISM, MACROSTOMIA, DYSOSTOSIS, MUTATIONS, DEFECTS
Aim: The term frontonasal dysplasia (FND) represents a spectrum of anomalies and its genetics have not been well defined. Recently, the critical role of the aristaless-like homeobox (ALX) gene family on the craniofacial development has been discovered. In the present study, we aimed to propose a systematic surgical treatment plan for the ALX-related FNDs according to the genotypic classification as well as demonstrating their clinical characteristics to help surgeons diagnose the underlying pathology accurately.