CDK4/6 inhibitors: mechanisms of resistance and potential biomarkers of responsiveness in breast cancer
FUTURE ONCOLOGY, vol.18, pp.1143-1157, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 18
- Publication Date: 2022
- Doi Number: 10.2217/fon-2021-0842
- Journal Name: FUTURE ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
- Page Numbers: pp.1143-1157
- Keywords: biomarkers, CDK 4, 6 inhibitors, endocrine resistance, endocrine therapy, HER2-negative breast cancer, hormone receptor (HR) positive, resistance mechanisms, CYTOPLASMIC CYCLIN-E, PALBOCICLIB, THERAPY, ABEMACICLIB, PROGRESSION, FULVESTRANT, EXPRESSION, PATHWAY, COMBINATION, MULTICENTER
- Süleyman Demirel University Affiliated: Yes
Abstract
Hormone receptor (HR)-positive, HER2-negative tumors represent the most common form of metastatic breast cancer (MBC), and endocrine therapy has been the mainstay treatment for several decades. Recently, a novel drug class called CDK4/6 inhibitors in combination with endocrine therapy have remarkably improved the outcome of patients with HR-positive, HER2-negative MBC by targeting the cell cycle machinery and overcoming aspects of endocrine resistance. Several potential cell-cycle-specific and nonspecific mechanisms of resistance to CDK4/6 inhibitors have been reported in recent studies. This review discusses potential resistance mechanisms to CDK4/6 inhibitors, the use of biomarkers to guide treatment for HR-positive, HER2-negative MBC and possible approaches to overcome resistance to CDK4/6 inhibitors.