Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient
Journal of Asian Natural Products Research, cilt.28, sa.4, ss.617-634, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 28 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/10286020.2025.2517669
- Dergi Adı: Journal of Asian Natural Products Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Applied Science & Technology Source, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.617-634
- Anahtar Kelimeler: anticancer agents, apoptosis, cancer, Carvacrol
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Apoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown to inhibit tumor growth and induce apoptosis in cancerous cells, increasing caspase activity, DNA fragmentation, and the expression of the Bax protein, while decreasing Bcl-2 expression. In this review, the effects of carvacrol on various cancers and its potential as a drug are summarized.