SIMIULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL PREPARATIONS BY RATIO SPECTRA DERIVATIVE METHOD

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Aktaş A. H., Sarı H.

Universal Journal of Pharmaceutical Research, cilt.8, sa.2, ss.40-43, 2023 (Hakemli Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 8 Sayı: 2
• Basım Tarihi: 2023
• Dergi Adı: Universal Journal of Pharmaceutical Research
• Derginin Tarandığı İndeksler: CAB Abstracts
• Sayfa Sayıları: ss.40-43
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Süleyman Demirel Üniversitesi Adresli: Evet

Özet

 As it is known, antihypertensive drugs are frequently used for the treatment of individuals with high blood pressure

all over the world. This study aims is to precisely determine the active substances of telmisartan and hydrochlorothiazide, which

are commercially sold as high blood pressure drugs in the market, and to use the ratio spectrum method for this purpose.

Method: All, solutions of the active ingredients of the drugs studied in the method were prepared in various concentrations.

Subsequently, mixtures were prepared in accordance with the commercial drug sample, their spectra were taken by

spectrophotometric method, and the spectrum ratio method was successfully applied to these data sets.

Results: The study revealed that the application of the ratio spectra first-order derivative spectrophotometric method yielded

highly reliable outcomes in the spectrophotometric analysis of different combinations of telmisartan and hydrochlorothiazide.