Synthesis and Enzymological Characterization of Some 2-(Substituted-phenylamino) quinazolin-4(3H)-one Derivatives as Potent alpha-Glucosidase Inhibitors In Vitro
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.18, sa.7, ss.723-732, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 7
- Basım Tarihi: 2021
- Doi Numarası: 10.2174/1570180818999201224121929
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
- Sayfa Sayıları: ss.723-732
- Anahtar Kelimeler: Quinazolin-4(3H)-one, aniline, alpha-glucosidase inhibitor, diabetes mellitus, kinetic study, synthesis, MOLECULAR DOCKING, BIOLOGICAL EVALUATION, DRUG DISCOVERY, SCREENING LIBRARIES, DESIGN, BENZIMIDAZOLE, COMBINATORIAL, CHEMISTRY, AGENTS
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Background: alpha-Glucosidase is an important hydrolytic enzyme playing a vital role in digestion of carbohydrates. It catalyzes the final step of carbohydrates digestion in biological systems and converts unabsorbed oligosaccharides and disaccharides into monosaccharides, thus resulting in hyperglycemia for diabetic patients. In this respect, it has been considered as a therapeutic target for the treatment of type 2 diabetes since the enzyme inhibition delays carbohydrate digestion and monosaccharide absorption and subsequently reduces postprandial plasma glucose levels.