Synthesis and Enzymological Characterization of Some 2-(Substituted-phenylamino) quinazolin-4(3H)-one Derivatives as Potent alpha-Glucosidase Inhibitors In Vitro

Ayan E. K., Soyer Z., Uysal S.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.18, no.7, pp.723-732, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.2174/1570180818999201224121929
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Page Numbers: pp.723-732
  • Keywords: Quinazolin-4(3H)-one, aniline, alpha-glucosidase inhibitor, diabetes mellitus, kinetic study, synthesis, MOLECULAR DOCKING, BIOLOGICAL EVALUATION, DRUG DISCOVERY, SCREENING LIBRARIES, DESIGN, BENZIMIDAZOLE, COMBINATORIAL, CHEMISTRY, AGENTS
  • Süleyman Demirel University Affiliated: No

Abstract

Background: alpha-Glucosidase is an important hydrolytic enzyme playing a vital role in digestion of carbohydrates. It catalyzes the final step of carbohydrates digestion in biological systems and converts unabsorbed oligosaccharides and disaccharides into monosaccharides, thus resulting in hyperglycemia for diabetic patients. In this respect, it has been considered as a therapeutic target for the treatment of type 2 diabetes since the enzyme inhibition delays carbohydrate digestion and monosaccharide absorption and subsequently reduces postprandial plasma glucose levels.