LETTERS IN DRUG DESIGN & DISCOVERY, vol.18, no.7, pp.723-732, 2021 (SCI-Expanded)
Article / Article
LETTERS IN DRUG DESIGN & DISCOVERY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
Quinazolin-4(3H)-one, aniline, alpha-glucosidase inhibitor, diabetes mellitus, kinetic study, synthesis, MOLECULAR DOCKING, BIOLOGICAL EVALUATION, DRUG DISCOVERY, SCREENING LIBRARIES, DESIGN, BENZIMIDAZOLE, COMBINATORIAL, CHEMISTRY, AGENTS
Süleyman Demirel University Affiliated:
Background: alpha-Glucosidase is an important hydrolytic enzyme playing a vital role in digestion of carbohydrates. It catalyzes the final step of carbohydrates digestion in biological systems and converts unabsorbed oligosaccharides and disaccharides into monosaccharides, thus resulting in hyperglycemia for diabetic patients. In this respect, it has been considered as a therapeutic target for the treatment of type 2 diabetes since the enzyme inhibition delays carbohydrate digestion and monosaccharide absorption and subsequently reduces postprandial plasma glucose levels.