Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis by Hypericum perforatum


NAZIROĞLU M. , KUTLUHAN S. , OVEY I. S. , AYKUR M., YÜREKLİ V. A.

NUTRITIONAL NEUROSCIENCE, vol.17, no.5, pp.214-221, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.1179/1476830513y.0000000083
  • Title of Journal : NUTRITIONAL NEUROSCIENCE
  • Page Numbers: pp.214-221

Abstract

Objectives: Hypericum perfortarum (HP, St John's wort) is a modulator of Ca2+ entry in neutrophils and it may modulate intracellular free Ca2+ ([Ca2+](i)) entry in leukocytes of patients with multiple sclerosis (MS). We investigated effects of HP on oxidative stress, apoptosis, and [Ca2+](i) concentrations in serum and leukocytes of patients with MS.