Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis by Hypericum perforatum

NAZIROĞLU M., KUTLUHAN S., OVEY I. S., AYKUR M., YÜREKLİ V. A.

NUTRITIONAL NEUROSCIENCE, vol.17, no.5, pp.214-221, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.1179/1476830513y.0000000083
  • Journal Name: NUTRITIONAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.214-221
  • Süleyman Demirel University Affiliated: Yes

Abstract

Objectives: Hypericum perfortarum (HP, St John's wort) is a modulator of Ca2+ entry in neutrophils and it may modulate intracellular free Ca2+ ([Ca2+](i)) entry in leukocytes of patients with multiple sclerosis (MS). We investigated effects of HP on oxidative stress, apoptosis, and [Ca2+](i) concentrations in serum and leukocytes of patients with MS.