Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress


ÇELİK Ö. , NAZIROĞLU M.

PHYSIOLOGY & BEHAVIOR, cilt.107, ss.458-465, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 107 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.physbeh.2012.09.013
  • Dergi Adı: PHYSIOLOGY & BEHAVIOR
  • Sayfa Sayıları: ss.458-465

Özet

Transient receptor potential melastatin-like 2 (TRPM2) is a non-selective Ca2+ permeable cation channel and is known to be activated by H2O2, one of the most important indicators of intracellular oxidative stress. A neurohormone melatonin may have a modulator role on TRPM2 channels activated by oxidative stress because it is a strong antioxidant. In this study we investigated the effects of melatonin on apoptosis, whole cell currents and Ca2+ influx arising from TRPM2 channels activated by H2O2.