Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress
PHYSIOLOGY & BEHAVIOR, cilt.107, sa.3, ss.458-465, 2012 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 107 Sayı: 3
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.physbeh.2012.09.013
- Dergi Adı: PHYSIOLOGY & BEHAVIOR
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Sayfa Sayıları: ss.458-465
- Anahtar Kelimeler: Melatonin, Oxidative stress, Ca2+ signaling, TRPM2 channel antagonist, Apoptosis, ADP-RIBOSE, HYDROGEN-PEROXIDE, CALCIUM INFLUX, CA2+ INFLUX, BORATE, POLY(ADP-RIBOSE), MECHANISMS, TOXICITY, LTRPC2
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Transient receptor potential melastatin-like 2 (TRPM2) is a non-selective Ca2+ permeable cation channel and is known to be activated by H2O2, one of the most important indicators of intracellular oxidative stress. A neurohormone melatonin may have a modulator role on TRPM2 channels activated by oxidative stress because it is a strong antioxidant. In this study we investigated the effects of melatonin on apoptosis, whole cell currents and Ca2+ influx arising from TRPM2 channels activated by H2O2.