PHYSIOLOGY & BEHAVIOR, vol.107, no.3, pp.458-465, 2012 (SCI-Expanded)
Article / Article
PHYSIOLOGY & BEHAVIOR
Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Melatonin, Oxidative stress, Ca2+ signaling, TRPM2 channel antagonist, Apoptosis, ADP-RIBOSE, HYDROGEN-PEROXIDE, CALCIUM INFLUX, CA2+ INFLUX, BORATE, POLY(ADP-RIBOSE), MECHANISMS, TOXICITY, LTRPC2
Süleyman Demirel University Affiliated:
Transient receptor potential melastatin-like 2 (TRPM2) is a non-selective Ca2+ permeable cation channel and is known to be activated by H2O2, one of the most important indicators of intracellular oxidative stress. A neurohormone melatonin may have a modulator role on TRPM2 channels activated by oxidative stress because it is a strong antioxidant. In this study we investigated the effects of melatonin on apoptosis, whole cell currents and Ca2+ influx arising from TRPM2 channels activated by H2O2.