The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review

Demiray A., AFŞAR B., Covic A., Kuwabara M., Ferro C. J., Lanaspa M. A., ...More

ANGIOLOGY, vol.73, no.1, pp.9-17, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 73 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1177/00033197211012546
  • Journal Name: ANGIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE
  • Page Numbers: pp.9-17
  • Keywords: coronary artery disease, inflammation, kidney disease, myocardial infarction, uric acid
  • Süleyman Demirel University Affiliated: Yes


Increased serum uric acid (SUA) levels have been associated with various pathologic processes such as increased oxidative stress, inflammation, and endothelial dysfunction. Thus, it is not surprising that increased SUA is associated with various adverse outcomes including cardiovascular (CV) diseases. Recent epidemiological evidence suggests that increased SUA may be related to acute myocardial infarction (AMI). Accumulating data also showed that elevated UA has pathophysiological role in the development of AMI. However, there are also studies showing that SUA is not related to the risk of AMI. In this narrative review, we summarized the recent literature data regarding SUA and AMI after providing some background information for the association between UA and coronary artery disease. Future studies will show whether decreasing SUA levels is beneficial for outcomes related to AMI and the optimum SUA levels for best outcomes in CV diseases.