Sclerostin, cardiovascular disease and mortality: a systematic review and meta-analysis
INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.48, sa.12, ss.2029-2042, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 48 Sayı: 12
- Basım Tarihi: 2016
- Doi Numarası: 10.1007/s11255-016-1387-8
- Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2029-2042
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Chronic kidney disease mineral and bone disorder (CKD-MBD) is associated with increased morbidity and mortality. Several cross-sectional studies investigated the association of serum sclerostin levels with mortality and vascular calcification. We aimed to investigate the effect of sclerostin on cardiovascular events (CVE), all-cause/cardiovascular mortality and vascular calcification in patients with CKD through systematic review and meta-analysis. The primary outcome was the association between sclerostin level and development of fatal and nonfatal CVE and all-cause mortality.