Aortic Elasticity is Impaired in Patients with Endemic Fluorosis


VAROL E. , AKCAY S., ERSOY I. H. , Ozaydin M. , KOROGLU B. K. , Varol S.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.133, ss.121-127, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 133 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s12011-009-8578-4
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Sayfa Sayıları: ss.121-127

Özet

Sixty-three patients with endemic fluorosis (36 males/27 females; mean age 33.9 +/- 8.6 years) and 45 age-, sex-, and body mass index-matched healthy controls (30 males/15 females; mean age 32.7 +/- 8.8 years) were included in this study. Aortic stiffness indices, aortic strain (AS), aortic distensibility (AD), and aortic strain index (ASI) were calculated from the aortic diameters measured by echocardiography and blood pressure obtained by sphygmomanometry. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.9 +/- 0.1 mg/l vs. 0.4 +/- 0.1 mg/l, respectively; P < 0.001). AS and AD were significantly lower in fluorosis patients than in the controls (for AS 5.3 +/- 3.6 vs. 8.0 +/- 3.4%; P < 0.001 and for AD 0.2 +/- 0.1 vs. 0.3 +/- 0.1 cm(2) dyn(-1) 10(-3); P < 0.001, respectively). In contrast, signicantly higher ASI was observed in fluorosis patients than in the controls (3.4 +/- 0.6 vs. 3.0 +/- 0.4; P < 0.001, respectively). The results of our study demonstrate that elastic properties of ascending aorta are impaired in patients with endemic fluorosis.