Solubility study of carvedilol in the aqueous mixtures of a choline chloride/propylene glycol deep eutectic solvent


Sayad T., Poturcu K. , Moradi M., Rahimpour E., Zhao H., Jouyban A.

JOURNAL OF MOLECULAR LIQUIDS, vol.342, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 342
  • Publication Date: 2021
  • Doi Number: 10.1016/j.molliq.2021.117537
  • Title of Journal : JOURNAL OF MOLECULAR LIQUIDS
  • Keywords: Carvedilol, Solubility, Deep eutectic solvent, Cosolvency, Mathematical modeling, Thermodynamic parameters, PREDICTING DRUG SOLUBILITY, PROPYLENE-GLYCOL, MODELS, CYCLODEXTRIN, DELIVERY

Abstract

Solubility behavior of a poorly soluble drug (carvedilol) has been studied in the aqueous mixtures of a deep eutectic solvent composed of choline chloride and propylene glycol at different temperatures (293.15-313.15) K. The obtained solubility data are correlated using some of the well-known cosolvency models such as the van't Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models. The accuracy of these mathematical models is investigated with the mean relative deviations of the back calculated solubility data. The apparent thermodynamic properties (i.e. Gibbs energy, enthalpy and entropy) of carvedilol in the investigated mixtures are also calculated with the van't Hoff and Gibbs equations at Thm. (C) 2021 Elsevier B.V. All rights reserved.