Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.68, no.3, pp.184-190, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 68 Issue: 3
- Publication Date: 2007
- Doi Number: 10.1016/j.curtheres.2007.06.003
- Journal Name: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.184-190
- Keywords: experimental endophthalmitis, fluoroquinolone, ofloxacin, lomefloxacin, lens, animal study, rabbit, TOPICALLY APPLIED CIPROFLOXACIN, LIQUID-CHROMATOGRAPHIC ASSAY, AQUEOUS-HUMOR LEVELS, VITREOUS-HUMOR, PENETRATION, LEVOFLOXACIN, NORFLOXACIN, FLUOROQUINOLONES, 0.3-PERCENT
- Süleyman Demirel University Affiliated: No
Abstract
Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes.