Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.68, sa.3, ss.184-190, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 3
- Basım Tarihi: 2007
- Doi Numarası: 10.1016/j.curtheres.2007.06.003
- Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.184-190
- Anahtar Kelimeler: experimental endophthalmitis, fluoroquinolone, ofloxacin, lomefloxacin, lens, animal study, rabbit, TOPICALLY APPLIED CIPROFLOXACIN, LIQUID-CHROMATOGRAPHIC ASSAY, AQUEOUS-HUMOR LEVELS, VITREOUS-HUMOR, PENETRATION, LEVOFLOXACIN, NORFLOXACIN, FLUOROQUINOLONES, 0.3-PERCENT
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes.