Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model


Yagci R., Oflu Y., Yagci S., Dincel A., Kaya E., Duman S., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.68, no.3, pp.184-190, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.curtheres.2007.06.003
  • Journal Name: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.184-190
  • Keywords: experimental endophthalmitis, fluoroquinolone, ofloxacin, lomefloxacin, lens, animal study, rabbit, TOPICALLY APPLIED CIPROFLOXACIN, LIQUID-CHROMATOGRAPHIC ASSAY, AQUEOUS-HUMOR LEVELS, VITREOUS-HUMOR, PENETRATION, LEVOFLOXACIN, NORFLOXACIN, FLUOROQUINOLONES, 0.3-PERCENT
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes.