Analysis of the binary mixtures of amlodipine and atorvastatin by chemometric-spectophotometric method
Manas Journal of Engineering, cilt.13, sa.1, ss.2-7, 2025 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.51354/mjen.1389474
- Dergi Adı: Manas Journal of Engineering
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.2-7
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
In
this thesis, the simultaneous quantification of amlodipine and atorvastatin in
pharmaceutical preparations was successfully accomplished without the need for
a separation process by using chemometric calibration methods (principal
component analysis method (PCA), principal component regression method (PCR),
and partial least squares method (PLS). Additionally, chemometric evaluation
was performed on the data obtained from UV visible field spectroscopy methods.
16 mixes containing the chemicals atorvastatin and amlodipine were created as a
calibration (concentration) set to assess the validity of the designated
chemometric procedures. The calibration set's absorption spectrum was captured
between 200 and 500 nm. The link between the calibration set and the absorption
data collected in the 215–355 nm region was used to produce three chemometric
calibrations. Amlodipine and atorvastatin synthetic mixtures were analyzed to
assess the validity of the PCA, PCR, and PLS approaches. The percentage (%)
recovery average for atorvastatin and amlodipine was determined for both the
drug sample and the synthetic mixture using the approach we used. It was
discovered that the computed values were fairly high.The methodologies were
controlled, and the ANOVA test was run using the results of the PLS and PCR
calibration techniques. The enhanced technique might be suggested for the
examination of medication samples containing atorvastatin and amlodipine since
it is among the most sensitive, accurate, and repeatable techniques available.