Synthesis, characterization, duplex-DNA interactions, and anticancer activities of novel octahedral [Ni(phen)(2)(dppz-idzo)](2+)and [Co(phen)(2)(dppz-idzo)](3+)complexes
APPLIED ORGANOMETALLIC CHEMISTRY, cilt.34, sa.10, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 10
- Basım Tarihi: 2020
- Doi Numarası: 10.1002/aoc.5866
- Dergi Adı: APPLIED ORGANOMETALLIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
- Anahtar Kelimeler: anticancer, DNA binding, dppz, dppz-idzo, phenazine, MOLECULAR LIGHT SWITCH, RUTHENIUM(II) POLYPYRIDYL COMPLEX, DIPYRIDOPHENAZINE COMPLEXES, POWERFUL STABILIZER, BIOLOGICAL-ACTIVITY, BINDING PROPERTIES, PHOTOCLEAVAGE, COBALT(III), NICKEL(II), DERIVATIVES
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Two new octahedral [Ni(phen)(2)(dppz-idzo)](2+)and [Co(phen)(2)(dppz-idzo)](3+)complexes have been synthesized and characterized by CHN analysis, electrospray ionization-MS, nuclear magnetic resonance, and UV-Vis spectra. The DNA-binding ability of these complexes was spectrophotometrically, hydrodynamically, and electrophoretically evaluated which indicated that they strongly intercalate into the DNA double helix, and that both induced severe DNA damage in the presence of peroxide. The complexes also showed strong antiproliferative effect against HepG2 and MDA-MB-231 cells. By contrast, they were found to be inactive against the MCF-7 cell line. The ligand itself was found to be inactive against the cells tested.